Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length470 amino acids

Chemical FormulaC2363H3709N587O687S17

DescriptionStandard

        MVKICCSLLLLSLLGGQLNANPGLKVRITQKGLEYAKEVGLEILKQNMEKDHFPDLSGYEKFGLGNVKYNISRIHITAVEFPSASISLVPGTGIKLVIGNASLTIDMNWNIRTWMFKDSGRSTVYISKVFVTAIFSTPLDNTGHTSIALTSCRTTSGDIDIKLSGKSGFLRNFFIKYLKKPIHRSLVTNSCPNIRSGIQLIDEDLRSLNVLMPIDDLAEVDYSLNSLPAVFQPFIDLDLKGIVYPAGNYTGPPYVAAPFTIPDQSDSMLHLAFSEYFFQTSSFAYYTAGAFSITIAEETCSYFNISTEIFGSIIPEVAKYSVTPYPVMLKLTATEIPIISLEQDSFTVEIRGSMEVFAVLPDSATQSLFTMNIAANTSIALNIFDQKLMGSLCLNRLQFSLAHSNVGFFEISLLENILSYILQTEVIPSANAKLSKGFPLPNLANVTLTRPHITIVQGYMLISTDVHYKH
    

Molecular Weight51878.35 Da

Isoelectric Point (pI)6.01

Net Charge (pH 7.0)-4.74

Net Charge (pH 7.4) -5.60

Charge Density (pH 7.0) -0.0101

GRAVY Index0.21

Hydrophobic Moment 0.77

Boman Index0.18

Instability Index39.42

Aliphatic Index 103.94

Aromaticity 0.1000

Extinction Coeff. Reduced 37820.00

Extinction Coeff. Oxidized 38195.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0029666 VERIFIED: NO

Provenance & Taxonomy

OrganismAquila chrysaetos chrysaetos [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria