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MYP_139767
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Basic Information
Tachyplesin ccTP [4,8,13R]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
18 amino acids
C86H152N38O19S6
Standard
Sequence
KWCRCVCRRGICRCRCRG
Physicochemical Analysis
2214.76 Da
9.99
6.70
6.41
0.3722
-0.49
0.64
-0.59
22.93
37.78
0.0556
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
971.23
-11.38
45.0
32.0
74.0
149.0
2.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0315545 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained cyclic beta-sheet peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-16; 5-14; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida tropicalis ATCC 37097
1.9 μM
MIC
PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0326915 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained cyclic beta-sheet peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-16; 5-14; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 25922
5.5 μM
MIC
PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0343598 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained cyclic beta-sheet peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
3-16; 5-14; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Klebsiella oxytoca ATCC 49131
2.4;5.4 μM
MIC (low-salt; high-salt)
PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0344473 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained cyclic beta-sheet peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
3-16; 5-14; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida tropicalis ATCC 37097
1.9;4.8 μM
MIC (low-salt; high-salt)
PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0369843 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained cyclic beta-sheet peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
3-16; 5-14; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida kefyr ATCC 37095
4.2;0.7 μM
MIC (low-salt; high-salt)
PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
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