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MYP_139767
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Basic Information
Tachyplesin ccTP [4,8,13R]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
18 amino acids
C86H152N38O19S6
Standard
Sequence
KWCRCVCRRGICRCRCRG
Physicochemical Analysis
2214.76 Da
9.99
6.70
6.41
0.3722
-0.49
0.64
-0.59
22.93
37.78
0.0556
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
971.23
-11.38
45.0
32.0
74.0
149.0
2.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0130856 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
3-16; 5-14; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
low-salt; MIC=5.1 μM in high-salt)
7.1 μM
MIC
PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0132540 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Enterococcus faecalis ATCC 29212
0.5 μM
MIC
PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0159546 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Proteus vulgaris ATCC 49132
16.8 μM
MIC
PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0192269 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
3-16; 5-14; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
low-salt; MIC=0.5 μM in high-salt)
0.7 μM
MIC
PaperMarked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-790. doi: 10.1006/bbrc.1999.2035. PMID: 10673369. PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
RECORD: Rec_0192964 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Klebsiella oxytoca ATCC 49131
2.4 μM
MIC
PMID10673369 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10673369/
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