Peptide Database

Peptide NameSLAY-screened peptide P3522

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC102H142N22O29S2

DescriptionStandard

        LPVDSSPPFVSCLYYHNYC
    

Molecular Weight2204.48 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-1.17

Net Charge (pH 7.4) -1.46

Charge Density (pH 7.0) -0.0618

GRAVY Index0.13

Hydrophobic Moment 0.32

Boman Index0.24

Instability Index138.26

Aliphatic Index 71.58

Aromaticity 0.2105

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4595.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 791.20

LogP -5.71

H-bond Donors 28.0

H-bond Acceptors 31.0

Rotatable Bonds 59.0

Heavy Atoms 155.0

Ring Count 8.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0234489 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/