Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length192 amino acids

Chemical FormulaC954H1521N261O261S10

DescriptionStandard

        PKALPVSREPMLLMAVTEFVANSAAFTYFTAGALRRNISSDMLPQKFPLQLRTKSMGVFSPQLQERYGDQPMELHLWARQQPLLSCHPDALHGTLFSSTEAFVVLPNTTRVPVFLLNIDANVTGKPTITRNRLGGTVRLTGLACTVDPLPALCQAQGLPIPQVKRLETLLKFGLWLFGVPRANSECCPHPVP
    

Molecular Weight21143.52 Da

Isoelectric Point (pI)9.38

Net Charge (pH 7.0)6.27

Net Charge (pH 7.4) 5.92

Charge Density (pH 7.0) 0.0327

GRAVY Index0.05

Hydrophobic Moment 0.54

Boman Index0.10

Instability Index60.63

Aliphatic Index 93.96

Aromaticity 0.0729

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8211.98

LogP -100.20

H-bond Donors 283.0

H-bond Acceptors 281.0

Rotatable Bonds 670.0

Heavy Atoms 1486.0

Ring Count 40.0

Amide Bonds 208.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0367469 VERIFIED: NO

Provenance & Taxonomy

OrganismTachuris rubrigastra [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria