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MYP_139600
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Basic Information
Antimicrobial Seed Protein/AC34H
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
37 amino acids
C161H255N49O48S6
Standard
Sequence
ACIKNGGRCVASGGPPYCCSNYCLQIAGQSYGVCKKH
Physicochemical Analysis
3837.44 Da
8.89
3.82
3.48
0.1032
-0.10
0.64
0.06
48.68
55.41
0.0811
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1555.72
-20.54
59.0
59.0
122.0
264.0
6.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0218021 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Bacillus cereus
PaperPubMed PMID 27208129 | PubMed PMID 10759490 PMID27208129;10759490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27208129/
RECORD: Rec_0231788 VERIFIED: YES
Provenance & Taxonomy
Phytolacca americana [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0240532 VERIFIED: YES
Provenance & Taxonomy
Phytolacca americana [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Lapidilactobacillus dextrinicus DSM 20293
90-100 % inhibition at >45 μg/mL
Growth inhibition
PMID27208129 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27208129/
RECORD: Rec_0344664 VERIFIED: YES
Provenance & Taxonomy
Phytolacca americana [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli MG1655
90-100 % inhibition at >45 μg/mL
Growth inhibition
PMID27208129 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27208129/
RECORD: Rec_0346210 VERIFIED: YES
Provenance & Taxonomy
Phytolacca americana [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa NCIMB 950
90-100 % inhibition at >45 μg/mL
Growth inhibition
PMID27208129 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27208129/
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