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MYP_139522
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Basic Information
LP-80
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
28 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WEQKIEELLKKAEEQQKKNEEELKKLEX
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0336967 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 89
PaperPubMed PMID: 30867304 PMID30867304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0345096 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C16(palmitic acid)
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 JRCSF; TZM-bl cells
0.000005±0.000001 μM
IC50
PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. J Virol. 2018 Sep 26;92(20):e01088-18. doi: 10.1128/JVI.01088-18. PMID: 30089693. PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/
RECORD: Rec_0347679 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antiviral
HIV-2
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0349951 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antimicrobial Antiviral
HIV-2(ROD,ST); TZM-bl cells
0.000288-0.000299 μM
IC50
PaperPubMed PMID: 30867304 PMID30867304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0357716 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C16(palmitic acid)
Bio-Activity Profile
Antiviral Anti-HIV Fusion inhibition
HIV-2 (ROD,ST) | TZM-bl cells
0.00006-0.00034 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. | Chong H, Zhu Y, Yu D, He Y. | J Virol. 2018 Sep 26;92(20):e01088-18. | DOI:10.1128/JVI.01088-18 | PMID:30089693 PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/
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