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MYP_139522
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Basic Information
LP-80
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
28 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WEQKIEELLKKAEEQQKKNEEELKKLEX
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0192844 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 D36G
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0195289 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 NL4-3 (X4) | TZM-bl cells
0.00000266±0.00000076 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperDesign and Characterization of Cholesterylated Peptide HIV-1/2 Fusion Inhibitors with Extremely Potent and Long-Lasting Antiviral Activity. | Zhu Y, Chong H, Yu D, Guo Y, Zhou Y, He Y. | J Virol. 2019 May 15;93(11):e02312-18. | DOI:10.1128/JVI.02312-18 | PMID:30867304 PMID30867304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0208540 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C16(palmitic acid)
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
T-20 resistant HIV-1 NL4-3 (WT,I37T,V38A,V38 M,Q40H,N43K,G36S/V38 M,I37T/N43K,V38A/N42T) | TZM-bl cells
0.00001-0.00186 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. | Chong H, Zhu Y, Yu D, He Y. | J Virol. 2018 Sep 26;92(20):e01088-18. | DOI:10.1128/JVI.01088-18 | PMID:30089693 PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/
RECORD: Rec_0220449 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 30867304 PMID30867304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0220851 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antiviral
HIV-1 JRCSF
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
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