‹ ›
MYP_139522
← PREVIOUS NEXT → BACK
Basic Information
LP-80
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
28 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WEQKIEELLKKAEEQQKKNEEELKKLEX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0177501 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 (1A,2B,1C,1G,1A/C,1A/E,1B/C subtype) | HEK293T cells; TZM-bl cells
0.0000134 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperDesign and Characterization of Cholesterylated Peptide HIV-1/2 Fusion Inhibitors with Extremely Potent and Long-Lasting Antiviral Activity. | Zhu Y, Chong H, Yu D, Guo Y, Zhou Y, He Y. | J Virol. 2019 May 15;93(11):e02312-18. | DOI:10.1128/JVI.02312-18 | PMID:30867304 PMID30867304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0182048 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antiviral
HIV-1
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0183492 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 pseudovirus | TZM-bl cells
0.000005 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperDesign and Characterization of Cholesterylated Peptide HIV-1/2 Fusion Inhibitors with Extremely Potent and Long-Lasting Antiviral Activity. | Zhu Y, Chong H, Yu D, Guo Y, Zhou Y, He Y. | J Virol. 2019 May 15;93(11):e02312-18. | DOI:10.1128/JVI.02312-18 | PMID:30867304 PMID30867304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0189124 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C16(palmitic acid)
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. J Virol. 2018 Sep 26;92(20):e01088-18. doi: 10.1128/JVI.01088-18. PMID: 30089693. PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/
RECORD: Rec_0189343 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antiviral Anti-HIV Fusion inhibition Cytotoxicity
MT-4 cells
218.37 μM
CC50 (CellTiter 96 AQueous One Solution assay)
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
FIRST PREV 1 2 3 4 5 6 ... 11 NEXT LAST
Showing 5 records · Page 4 of 11