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MYP_139522
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Basic Information
LP-80
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
28 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WEQKIEELLKKAEEQQKKNEEELKKLEX
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0084754 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antimicrobial Antiviral
T-20 sensitive HIV-1(NL4-3D36G):inhibition of virus infection in TZM-bl cells
0.000003±0.000001 μM
IC50
PaperPubMed PMID: 30867304 PMID30867304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0096287 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 28
Bio-Activity Profile
Antiviral
Human adenocarcinoma TZM-bl[50-60% Cytotoxicity = 62.33 microM
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0108948 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 28
Bio-Activity Profile
Antiviral
HIV-1 HxB2
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0115570 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1(1A,2B,1C,1G,1A/C,1A/E,1B/C subtype):inhibition of cell-cell fusion between HEK293T cells and TZM-bl cells
0.000013 μM
IC50
PaperPubMed PMID: 30867304 PMID30867304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0123028 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 JR-CSF(R5):inhibition of virus replication in TZM-bl cells
0.000007±0 μM
IC50
PaperPubMed PMID: 30867304 PMID30867304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
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