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MYP_139522
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Basic Information
LP-80
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
28 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WEQKIEELLKKAEEQQKKNEEELKKLEX
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0416106 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antiviral Anti-HIV Fusion inhibition Cytotoxicity
HEK293T cells
72.23 μM
CC50 (CellTiter 96 AQueous One Solution assay)
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0422472 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear lipopeptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The X at position 28 is Lys-C18(stearic acid)
Bio-Activity Profile
Antiviral
HIV-1 NL4-3
PMID30867304;30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
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