Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length566 amino acids

Chemical FormulaC2811H4461N777O791S23

DescriptionStandard

        MVGPAVPVMWDTLPACHAFRCQHRPRGVVWLCLLLLLPVCVPATVTNPGIKAWLTQSSLEFGRRFGLELFQSTLQKEHELNLTGSYNIPLLGNLTYAVPRIHIHELQMNDSTLDFAEDVGVRLMVQRAQIQLSADWAAQLGAIQDSGSVELRMQDLAVAAVLGVSDDGGGRPTVWSAGCDTHGTDLHMEFHRGYSWIYNLLAPLLQRTLRQQLNKQLCLELQRGIDKLDAALKHMKVSTQLDAFAAIDYSLLGPPAFTAEHGDIALKGEIFRVGMYQQRRSAPPVALPVALPMSLPVALPVALPLALPTLTPKALPMAREPMMLMAVTEFVANSAAFTYFTAGALRRNISSDMLPQRFPFQLRTKSMGVFSPQLQERYGDQPMELHLWARRQPLLSCHPDALHGTLFSSAEAFVVLPNTTRVPVFLLNIDANVTGKPTITKNRLGGTVRLTELSVTQVASNVGPVEVKRLETLLKFGLWLFGVPRANKWLQAGIPLPLPHGLSLLRPRVLLQERSRLGTDEHGPTAIYIRKEEEEEDQEDKEPFQQDTALGLVHHPNPGLDAAPSS
    

Molecular Weight62534.72 Da

Isoelectric Point (pI)6.79

Net Charge (pH 7.0)-1.01

Net Charge (pH 7.4) -2.29

Charge Density (pH 7.0) -0.0018

GRAVY Index-0.02

Hydrophobic Moment 0.70

Boman Index0.09

Instability Index52.45

Aliphatic Index 99.10

Aromaticity 0.0689

Extinction Coeff. Reduced 62910.00

Extinction Coeff. Oxidized 63285.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0312922 VERIFIED: NO

Provenance & Taxonomy

OrganismLepidothrix coronata [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria