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MYP_139359
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Basic Information
Fungal defensin copsin
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Listeria
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
184 amino acids
C794H1296N234O264S19
Standard
Sequence
MKLSTSLLAIVAVASTFIGNALSATTVPGCFAECIDKAAVAVNCAAGDIDCLQASSQFATIVSECVATSDCTALSPGSASDADSINKTFNILSGLGFIDEADAFSAADVPEERDLTGLGRVLPVEKRQNCPTRRGLCVTSGLTACRNHCRSCHRGDVGCVRCSNAQCTGFLGTTCTCINPCPRC
Physicochemical Analysis
18953.43 Da
5.29
-3.48
-4.08
-0.0189
0.25
0.69
0.09
49.15
81.74
0.0380
0.00
1125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
7926.30
-107.75
294.0
282.0
615.0
1311.0
16.0
195.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001111 VERIFIED: YES
Provenance & Taxonomy
Coprinopsis cinerea [Fungus]
Defensin
240176
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
N-terminal pyroglutamate
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antilisterial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Antibacterial
Bacillus subtilis
Antibacterial growth-inhibition/bactericidal spectrum assay; peptidoglycan-precursor binding study
PaperCopsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis; Structural Insights into the Mode of Action of the Peptide Antibiotic Copsin PMID25342741;28825809 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25342741/
RECORD: Rec_0011654 VERIFIED: YES
Provenance & Taxonomy
Coprinopsis cinerea [Fungus]
Defensin
240176
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
N-terminal pyroglutamate
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antilisterial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Antibacterial
Listeria monocytogenes
Antibacterial growth-inhibition/bactericidal spectrum assay; peptidoglycan-precursor binding study
PaperCopsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis; Structural Insights into the Mode of Action of the Peptide Antibiotic Copsin PMID25342741;28825809 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25342741/
RECORD: Rec_0140936 VERIFIED: YES
Provenance & Taxonomy
Coprinopsis cinerea [Fungus]
Defensin
240176
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
N-terminal pyroglutamate
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antilisterial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Antibacterial
Enterococcus faecium
Antibacterial growth-inhibition/bactericidal spectrum assay; peptidoglycan-precursor binding study
PaperCopsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis; Structural Insights into the Mode of Action of the Peptide Antibiotic Copsin PMID25342741;28825809 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25342741/
RECORD: Rec_0278520 VERIFIED: YES
Provenance & Taxonomy
Coprinopsis cinerea [Fungus]
Defensin
240176
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
N-terminal pyroglutamate
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antilisterial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Antibacterial
Pseudomonas aeruginosa
Antibacterial growth-inhibition/bactericidal spectrum assay; peptidoglycan-precursor binding study
PaperCopsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis; Structural Insights into the Mode of Action of the Peptide Antibiotic Copsin PMID25342741;28825809 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25342741/
RECORD: Rec_0422251 VERIFIED: YES
Provenance & Taxonomy
Coprinopsis cinerea [Fungus]
Defensin
240176
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
N-terminal pyroglutamate
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antilisterial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Antibacterial
Bacillus anthracis
Antibacterial growth-inhibition/bactericidal spectrum assay; peptidoglycan-precursor binding study
PaperCopsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis; Structural Insights into the Mode of Action of the Peptide Antibiotic Copsin PMID25342741;28825809 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25342741/