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MYP_139301
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Basic Information
LS-Cathelicidin-BF-15-a1-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
Standard
15 amino acids
C103H161N27O16
Standard
Sequence
VKRFKKFFRKFKKFV
Physicochemical Analysis
2033.55 Da
12.00
7.73
7.51
0.5152
-0.67
0.97
-0.40
9.11
38.67
0.3333
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
750.64
-0.99
28.0
24.0
73.0
146.0
5.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0214673 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 2 and 6) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (2) and Ⓚ (6) are cross-linked by a but-2-ynyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus BNCC 186335
4 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0219771 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
benzyl/aryl-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 2 and 6) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (2) and Ⓚ (6) are cross-linked by 1,2-bismethylenebenzene via N-alkylation reaction
Bio-Activity Profile
Cytotoxicity
Human embryonic kidney HEK293T cells
128 μg/mL
LC50
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0220372 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 6 and 10) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (6) and Ⓚ (10) are cross-linked by a but-2-ynyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Cytotoxicity
Human embryonic kidney HEK293T cells
128 μg/mL
LC90
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0231410 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
benzyl/aryl-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 2 and 6) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (2) and Ⓚ (6) are cross-linked by 1,2-bismethylenebenzene via N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa
16 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0233202 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
benzyl/aryl-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 6 and 10) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (6) and Ⓚ (10) are cross-linked by 1,2-bismethylenebenzene via N-alkylation reaction
Bio-Activity Profile
Hemolytic
human red blood cells
32 μg/mL
MHC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
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