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MYP_139301
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Basic Information
LS-Cathelicidin-BF-15-a1-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
Standard
15 amino acids
C103H161N27O16
Standard
Sequence
VKRFKKFFRKFKKFV
Physicochemical Analysis
2033.55 Da
12.00
7.73
7.51
0.5152
-0.67
0.97
-0.40
9.11
38.67
0.3333
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
750.64
-0.99
28.0
24.0
73.0
146.0
5.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0160612 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 6 and 10) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (6) and Ⓚ (10) are cross-linked by a but-2-ynyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
2 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0168098 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 6 and 10) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (6) and Ⓚ (10) are cross-linked by a but-2-ynyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus (MRSA)
4 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0170579 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
16 μg/mL
MIC
PMID31843919 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31843919/
RECORD: Rec_0178997 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
lysine-tethered side-chain stapled peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓚ (position: 2 and 6) in sequence indicates Nε-o-Ns-Nα-Fmoc-lysine before stapling. Ⓚ (2) and Ⓚ (6) are cross-linked by a but-2-ynyl spacer employing the N-alkylation reaction
Bio-Activity Profile
Antimicrobial Antibacterial
Listeria monocytogenes
8 μg/mL
MIC
PaperHu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J. Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo. J Med Chem. 2022 Jan 13;65(1):579-591. PMID34968054 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34968054/
RECORD: Rec_0179336 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli BNCC 133264
2 μg/mL
MIC
PMID31843919 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31843919/
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