Peptide Database

Peptide NamesDRIM

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length26 amino acids

Chemical FormulaC129H223N39O34

DescriptionStandard

        QQRKRKIWSKLAPDGTTLVKLVAGIG
    

Molecular Weight2864.39 Da

Isoelectric Point (pI)11.17

Net Charge (pH 7.0)4.76

Net Charge (pH 7.4) 4.55

Charge Density (pH 7.0) 0.1830

GRAVY Index-0.33

Hydrophobic Moment 0.49

Boman Index-0.09

Instability Index16.63

Aliphatic Index 105.00

Aromaticity 0.0385

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1209.87

LogP -10.97

H-bond Donors 43.0

H-bond Acceptors 39.0

Rotatable Bonds 99.0

Heavy Atoms 202.0

Ring Count 3.0

Amide Bonds 27.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0159137 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralityall-D amino-acid peptide [D]

N-TermNone

C-TermAmidation

Other Modsⓚ (10) and ⓓ (14) are corss-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity10 μg/mL

MethodHemolysis

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

RECORD: Rec_0178081 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralityall-D amino-acid peptide [D]

N-TermNone

C-TermAmidation

Other Modsⓚ (10) and ⓓ (14) are corss-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity20 μg/mL

MethodHemolysis

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

RECORD: Rec_0183799 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralityall-D amino-acid peptide [D]

N-TermNone

C-TermAmidation

Other Modsⓚ (10) and ⓓ (14) are corss-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEnterococcus faecalis

Activity64 μg/mL

MethodMIC

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

RECORD: Rec_0211468 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralityall-D amino-acid peptide [D]

N-TermNone

C-TermAmidation

Other Modsⓚ (10) and ⓓ (14) are corss-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity15 μg/mL

MethodHemolysis

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

RECORD: Rec_0232227 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralityall-D amino-acid peptide [D]

N-TermNone

C-TermAmidation

Other Modsⓚ (10) and ⓓ (14) are corss-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity30 μg/mL

MethodHemolysis

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

FIRST PREV 1 2 3 4 NEXT LAST

Showing 5 records on this page Ã‚Â· Page 2 of 4