Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2437H3882N650O683S24

DescriptionStandard

        MREDMARGLHDASRWASLLVLVAVGTTVTAAANPGVVVRISQKGLDYASQQGTAALQKELKRIKIPDYSGSFKIKLLGKGRYSFYSMDIREFQLPSCQISMVPSVGLKFSISNANIKISGKWKARKRFIKTSGNFDLSVEGVSISADLKLGSNSTSGKPTVTCSSCSSHINRVHVRISKSRVGWLIRLFRKKIESTLRNKLNSQVCEKVTSSVSSELQPYFQTLPVMTKIDAVAGINYGLVAPPTTMAETLDVQMKGEFYSQNHHNPPPFAPPVMEFPAAHDHMVYLGLSDYFFNTAGLVYQQAGVLKMTLRDDMIPKESKFRLTTKFFGNFLPEVAKMFPNMKIQIHVSASTPPQLSVQPTGLTFYPAVDVQTFAVLPNSSLASLFLIGMHTTASMEVGAKSDRLVGKLKVDRLLLELKHSNIGPFPVELMQSIMNYIVPTFVLPRVNEKLQKGCPLPMPARVQVYNMVLQPYQNFLLFGADVVYK
    

Molecular Weight53984.40 Da

Isoelectric Point (pI)9.74

Net Charge (pH 7.0)23.34

Net Charge (pH 7.4) 22.43

Charge Density (pH 7.0) 0.0479

GRAVY Index-0.03

Hydrophobic Moment 0.77

Boman Index0.08

Instability Index36.90

Aliphatic Index 90.23

Aromaticity 0.0883

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0138968 VERIFIED: NO

Provenance & Taxonomy

OrganismRhinopithecus bieti [Animal]

FamilyBPI/LBP

Tax ID61621

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria