MYP_139247
Nisin A
Anticancer
Anticancer
▸
Cytotoxic anticancer activity
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Cytotoxic
Antimicrobial
Antimicrobial
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Antibacterial
Antimicrobial
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Antibacterial
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Anti-Gram-positive
Antimicrobial
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Anti-biofilm
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Biofilm inhibition
Reproductive biology
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Contraceptive activity
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Spermicidal
Toxicity / Safety
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Cytotoxicity
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Cytotoxic
Venom / Toxin
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General toxin
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Cytotoxic
Venom / Toxin
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General toxin
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Toxic
Wound healing/Regeneration
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Wound healing
Standard
34 amino acids
C143H246N42O45S7
Standard
ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK
3498.19 Da
8.78
2.88
2.50
0.0848
0.41
0.29
0.17
27.52
71.76
0.0000
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1375.41
-19.05
54.0
57.0
115.0
237.0
3.0
34.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0294726
VERIFIED: YES
Provenance & Taxonomy
Bacteria [Bacterium]
Lantibiotic
2;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm
Antibacterial
Staphylococcus aureus ATCC 43300
0.458 μM
Crystal violet assay
RECORD: Rec_0339453
VERIFIED: YES
Provenance & Taxonomy
Bacteria [Bacterium]
Lantibiotic
2;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm
Antibacterial
Staphylococcus aureus ATCC 6538
2.861 μM
Crystal violet assay
RECORD: Rec_0339769
VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
initially observed in inhibiting other bacteria. First lantibiotic discovered. The establishment of the sequence and structure was a long journey. Four genes are involved in immunity: nisFEG and nisI, where nisFEG encode an ABC transporter and nisI encodes an immunity protein that binds nisin. Chemical modification. Shown is the amino acid sequence derived from nucleotide and the actual active form is a translationally modified peptide. There are two di-hydroalanines (Dha): S5 and S33; one di-dehydrobutyrine (Dhb): T2; one lanthionine: S3-C7; and four methyllanthionines: T8-C11, T13-C19, T23-C26, and T25-C28 (Gross E, Morell JL 1971 J Am Chem Soc 93: 4634) (Provided by Torsten Stein)
Bio-Activity Profile
Antimicrobial
Anticancer
Spermicidal
Wound healing
H. influenzae
66.9 μg/mL
MIC
RECORD: Rec_0339794
VERIFIED: YES
Provenance & Taxonomy
Bacteria [Bacterium]
Lantibiotic
2;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm
Antibacterial
Staphylococcus aureus ATCC 43300
4.577, 0.458, 0.046 μM
Crystal violet assay
RECORD: Rec_0353250
VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Lantibiotic
1360
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibacterial
Showing 5 records on this page · Page 5 of 6