MYP_139247
Nisin A
Anticancer
Anticancer
▸
Cytotoxic anticancer activity
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Cytotoxic
Antimicrobial
Antimicrobial
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Antibacterial
Antimicrobial
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Antibacterial
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Anti-Gram-positive
Antimicrobial
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Anti-biofilm
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Biofilm inhibition
Reproductive biology
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Contraceptive activity
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Spermicidal
Toxicity / Safety
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Cytotoxicity
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Cytotoxic
Venom / Toxin
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General toxin
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Cytotoxic
Venom / Toxin
▸
General toxin
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Toxic
Wound healing/Regeneration
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Wound healing
Standard
34 amino acids
C143H246N42O45S7
Standard
ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK
3498.19 Da
8.78
2.88
2.50
0.0848
0.41
0.29
0.17
27.52
71.76
0.0000
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1375.41
-19.05
54.0
57.0
115.0
237.0
3.0
34.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0155983
VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
There are two dehydroalanines (S5; S33), one dehydrobutyrine (T2), which form one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Lactococcus
RECORD: Rec_0160704
VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
There are two dehydroalanines (S5; S33), one dehydrobutyrine (T2), which form one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Enterococcus
RECORD: Rec_0179369
VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
initially observed in inhibiting other bacteria. First lantibiotic discovered. The establishment of the sequence and structure was a long journey. Four genes are involved in immunity: nisFEG and nisI, where nisFEG encode an ABC transporter and nisI encodes an immunity protein that binds nisin. Chemical modification. Shown is the amino acid sequence derived from nucleotide and the actual active form is a translationally modified peptide. There are two di-hydroalanines (Dha): S5 and S33; one di-dehydrobutyrine (Dhb): T2; one lanthionine: S3-C7; and four methyllanthionines: T8-C11, T13-C19, T23-C26, and T25-C28 (Gross E, Morell JL 1971 J Am Chem Soc 93: 4634) (Provided by Torsten Stein)
Bio-Activity Profile
Antimicrobial
Anticancer
Spermicidal
Wound healing
Neisseria spp
8.4 μg/mL
MIC
RECORD: Rec_0228022
VERIFIED: YES
Provenance & Taxonomy
Bacteria [Bacterium]
Lantibiotic
2;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm
Antibacterial
Listeria monocytogenes ATCC 7644
0.1, 0.5, 1 μM
Safranin staining
RECORD: Rec_0228974
VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
initially observed in inhibiting other bacteria. First lantibiotic discovered. The establishment of the sequence and structure was a long journey. Four genes are involved in immunity: nisFEG and nisI, where nisFEG encode an ABC transporter and nisI encodes an immunity protein that binds nisin. Chemical modification. Shown is the amino acid sequence derived from nucleotide and the actual active form is a translationally modified peptide. There are two di-hydroalanines (Dha): S5 and S33; one di-dehydrobutyrine (Dhb): T2; one lanthionine: S3-C7; and four methyllanthionines: T8-C11, T13-C19, T23-C26, and T25-C28 (Gross E, Morell JL 1971 J Am Chem Soc 93: 4634) (Provided by Torsten Stein)
Bio-Activity Profile
Antimicrobial
Anticancer
Spermicidal
Wound healing
A. viscosus
83.6 μg/mL
MIC
Showing 5 records on this page · Page 3 of 6