MYP_139247
Nisin A
Anticancer
Anticancer
▸
Cytotoxic anticancer activity
▸
Cytotoxic
Antimicrobial
Antimicrobial
▸
Antibacterial
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-positive
Antimicrobial
▸
Anti-biofilm
▸
Biofilm inhibition
Reproductive biology
▸
Contraceptive activity
▸
Spermicidal
Toxicity / Safety
▸
Cytotoxicity
▸
Cytotoxic
Venom / Toxin
▸
General toxin
▸
Cytotoxic
Venom / Toxin
▸
General toxin
▸
Toxic
Wound healing/Regeneration
▸
Wound healing
Standard
34 amino acids
C143H246N42O45S7
Standard
ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK
3498.19 Da
8.78
2.88
2.50
0.0848
0.41
0.29
0.17
27.52
71.76
0.0000
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1375.41
-19.05
54.0
57.0
115.0
237.0
3.0
34.0
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
RECORD: Rec_0022448
VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
initially observed in inhibiting other bacteria. First lantibiotic discovered. The establishment of the sequence and structure was a long journey. Four genes are involved in immunity: nisFEG and nisI, where nisFEG encode an ABC transporter and nisI encodes an immunity protein that binds nisin. Chemical modification. Shown is the amino acid sequence derived from nucleotide and the actual active form is a translationally modified peptide. There are two di-hydroalanines (Dha): S5 and S33; one di-dehydrobutyrine (Dhb): T2; one lanthionine: S3-C7; and four methyllanthionines: T8-C11, T13-C19, T23-C26, and T25-C28 (Gross E, Morell JL 1971 J Am Chem Soc 93: 4634) (Provided by Torsten Stein)
Bio-Activity Profile
Antimicrobial
Anticancer
Spermicidal
Wound healing
C. jejune
1.1 μg/mL
MIC
RECORD: Rec_0034924
VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
There are two dehydroalanines (S5; S33), one dehydrobutyrine (T2), which form one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Listeria
RECORD: Rec_0052311
VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
initially observed in inhibiting other bacteria. First lantibiotic discovered. The establishment of the sequence and structure was a long journey. Four genes are involved in immunity: nisFEG and nisI, where nisFEG encode an ABC transporter and nisI encodes an immunity protein that binds nisin. Chemical modification. Shown is the amino acid sequence derived from nucleotide and the actual active form is a translationally modified peptide. There are two di-hydroalanines (Dha): S5 and S33; one di-dehydrobutyrine (Dhb): T2; one lanthionine: S3-C7; and four methyllanthionines: T8-C11, T13-C19, T23-C26, and T25-C28 (Gross E, Morell JL 1971 J Am Chem Soc 93: 4634) (Provided by Torsten Stein)
Bio-Activity Profile
Antimicrobial
Anticancer
Spermicidal
Wound healing
Clostridium spp
1.1 μg/mL
MIC
RECORD: Rec_0067079
VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
There are two dehydroalanines (S5; S33), one dehydrobutyrine (T2), which form one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Lactobacillus
RECORD: Rec_0072990
VERIFIED: NO
Provenance & Taxonomy
Streptococcus lactis [Bacterium]; Bacteria [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Showing 5 records on this page · Page 1 of 6