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MYP_139165
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Basic Information
Angiotensin I-converting enzyme inhibitor AV
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Standard
2 amino acids
C8H16N2O3
Standard
Sequence
AV
Physicochemical Analysis
188.22 Da
5.57
-0.20
-0.39
-0.1021
3.00
0.57
0.85
5.00
195.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
92.42
-0.44
3.0
3.0
4.0
13.0
0.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0217398 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic DPP-IV inhibitory
human dipeptidyl peptidase IV
PaperLan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.. Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015. PMID25577052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25577052/
RECORD: Rec_0251860 VERIFIED: YES
Provenance & Taxonomy
Sardine fermented [Animal]; Actinopterygii [Animal]
33208; 7898
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PMID16233562 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16233562/
RECORD: Rec_0310031 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 0.0%, C 100.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0328881 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
956.28
IC50
PaperSalampessy J., Reddy N., Kailasapathy K., Phillips M.. Functional and potential therapeutic ACE-inhibitory peptides derived from bromelain hydrolysis of trevally proteins. J. Funct. Foods 14, 716-725, 2015.
RECORD: Rec_0357376 VERIFIED: YES
Provenance & Taxonomy
Sardina pilchardus [Animal]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory Insulin-secretion stimulatory
ACE
15 %
ACE inhibition
PaperAngiotensin I-converting enzyme inhibitory activity and insulin secretion stimulative activity of fermented fish sauce PMID16233562 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16233562/
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