Peptide Database

Peptide NameycgE signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory enzyme production ▸ Alkaline protease secretion

Biotechnology / Production and expression ▸ Secretory expression optimization

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC176H296N56O52S

DescriptionStandard

        MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQAL
    

Molecular Weight4060.64 Da

Isoelectric Point (pI)11.55

Net Charge (pH 7.0)3.59

Net Charge (pH 7.4) 3.32

Charge Density (pH 7.0) 0.0998

GRAVY Index-0.33

Hydrophobic Moment 0.72

Boman Index-0.14

Instability Index43.54

Aliphatic Index 84.17

Aromaticity 0.0556

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1798.71

LogP -20.94

H-bond Donors 65.0

H-bond Acceptors 58.0

Rotatable Bonds 140.0

Heavy Atoms 285.0

Ring Count 3.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0016513 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis subsp. subtilis str. 168 [Bacterium]

FamilyTat signal peptide

Tax ID224308

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Alkalineprotease (alk) secretion

TargetBacillus amyloliquefaciens 111018

Activity13327.4 U/mL

MethodProtease activity assay

PaperLiu Y, Shi C, Li D, et al. Engineering a highly efficient expression system to produce BcaPRO protease in Bacillus subtilis by an optimized promoter and signal peptide[J]. International journal of biological macromolecules, 2019, 138: 903-911. PMID31356949 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31356949/