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MYP_139097
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Basic Information
NS5A-derived peptide C5A [I10A]
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-HIV ▸ HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C106H149N25O29S
Standard
Sequence
SWLRDIWDWACEVLSDFK
Physicochemical Analysis
2269.53 Da
4.23
-2.54
-2.77
-0.1414
-0.18
0.68
0.07
30.52
86.67
0.2222
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
882.97
-3.54
33.0
28.0
70.0
161.0
7.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0038187 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Free
Free
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
human erythrocytes
14.10 μM
MHC
PaperRational design of peptides with anti-HCV/HIV activities and enhanced specificity. Chem Biol Drug Des. 2011 Nov;78(5):835-843. doi: 10.1111/j.1747-0285.2011.01201.x. PMID: 21801309. PMID21801309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21801309/
RECORD: Rec_0044157 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Free
Free
Bio-Activity Profile
Antiviral
pseudotyped HIV-1; TZM-BL cells
2.21±0.28 μM
IC50 (pseudotyped HIV infection assay)
PMID21801309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21801309/
RECORD: Rec_0067742 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Free
Free
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
HCVcc in Huh7.5.1 cells; pseudotyped HIV-1 in TZM-BL cells; human erythrocytes
4.00±0.36; 2.21±0.28; 14.10 μM
IC50 (HCV infection); IC50 (pseudotyped HIV infection); MHC
PaperRational design of peptides with anti-HCV/HIV activities and enhanced specificity. Chem Biol Drug Des. 2011 Nov;78(5):835-843. doi: 10.1111/j.1747-0285.2011.01201.x. PMID: 21801309. PMID21801309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21801309/
RECORD: Rec_0110027 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Free
Free
Bio-Activity Profile
Antiviral Toxic Antimicrobial Hemolytic
HCVcc in Huh7.5.1 cells; pseudotyped HIV-1 in TZM-BL cells; human erythrocytes
4.00±0.36; 2.21±0.28; 14.10 μM
IC50 (HCV infection); IC50 (pseudotyped HIV infection); MHC
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0154822 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Free
Free
Bio-Activity Profile
Antiviral
Hepatitis C virus (HCVcc); Huh7.5.1 cells
4.00±0.36 μM
IC50 (HCV production and infection assay)
PMID21801309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21801309/