Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2295H3627N619O655S10

DescriptionStandard

        TNPGFVVRITQAGLDYAHQQGITMLEKQLAQLKLSDISGDSRVGRVGKVRYELSRLRLRDFHLPYSRITPISNVGLQVSISNAFAELDGDWRVKFYFVRDHGSFDVKVENVYVKISLRLGSDATGKPTVSTSDCSTRISKVRVLFSGKLGWLYNLFHSVIESRFRKILEDKVCDTVVESVHNELQTYVRTLPVTARIDAKTGIDYSLVAPPRATALSLDADLKGEFYSLASRSTIPFSPLPLAFPSDHDRMVYFGASSYFFNTAGIAYHEAGALVFEITEDMIPKDAGFSLDTSIFSAFIPQLEEMYPNMPMKFRLSTPTAPFLTIGPEGISLRPIVDAQAYAILPDASLAPLFLLSLVRNVSAVINVRSGHIVGSLNVGRIRLSLKDSAVGTFQVRTMQSLMNILTSSTLLPRLNARLDEGFPLPLPDRIQLSNILVRFHQNFLLLGADVHFQPR
    

Molecular Weight50690.75 Da

Isoelectric Point (pI)9.04

Net Charge (pH 7.0)5.30

Net Charge (pH 7.4) 4.48

Charge Density (pH 7.0) 0.0116

GRAVY Index0.06

Hydrophobic Moment 0.63

Boman Index0.08

Instability Index33.15

Aliphatic Index 101.32

Aromaticity 0.0943

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 31985.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0355469 VERIFIED: NO

Provenance & Taxonomy

OrganismPtilorrhoa leucosticta [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria