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MYP_138962
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Basic Information
Brevinin-1SA
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C120H192N28O27S2
Standard
Sequence
FLPAIVGAAGQFLPKIFCAISKKC
Physicochemical Analysis
2523.11 Da
9.39
2.74
2.50
0.1141
1.08
0.58
0.40
16.37
110.00
0.1250
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
856.42
-3.98
30.0
32.0
80.0
177.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0086459 VERIFIED: YES
Provenance & Taxonomy
Rana sphenocephala [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
55 μM
MIC
PaperPeptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala.
RECORD: Rec_0135643 VERIFIED: NO
Provenance & Taxonomy
Amphibia [Animal]
Brevinin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0174990 VERIFIED: YES
Provenance & Taxonomy
Rana sphenocephala [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
55 μM
MIC
PMID10604597 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10604597/
RECORD: Rec_0178103 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 58.3%, C 41.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-negative
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0232590 VERIFIED: YES
Provenance & Taxonomy
Lithobates sphenocephalus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
55.0 μM
MIC
PaperJ.M. Conlon et al. / J. Peptide Res. 54 (1999) 522-527. Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala Evidence URLhttps://www.uniprot.org/uniprotkb/P82904/entry
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