Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length590 amino acids

Chemical FormulaC3013H4688N770O858S19

DescriptionStandard

        MRRKNNFVGCNHWDGRSDPTRGGPRVLEENQNIAKALPGFKVLWRTIPQHFRAEFKAQVKNTLTSKAEGIEGAPQFWTLPLLKMCTKMVQVLWGCFLLWNLYISSTQTTYPGIKARATQRALDYGVQAGVLMIEQMIKERNIPDLKGSESLEFLKVDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTNWDVKSPLFQDTGGADLFLSGIYFTGILILAQNDFGQPTLKLQDCYAQVSHAHVSFTGELSVLYNSFAEPMEKPILKNLNEMLCPIITGEVEALNANLSMLEVLTKIDNYTLLDYSLMSSPEITENYIDLNLKGVFYPLENLTDPPFSPLPFVLPERSDSMFYIGISEYFFKSASFAHFTAGAFNITLSTKEISSHLVRHSQGVGNVLSRIAEIYILSQPFMVRIMATEPPVISLLPGNFTLDIPASIVILTQSENSTAETIVSMDFVASTSVSLVILGQRLICSLSLNRFRLSLPESNRSNIEVLRFENILSFILHFGILPLANAKLQQGFPLPNPHKISFVNSDIEVLEHFLLISTDLKYETPLKQQPSFYGWEGLNLISGRWRGKSVP
    

Molecular Weight66035.33 Da

Isoelectric Point (pI)6.29

Net Charge (pH 7.0)-3.53

Net Charge (pH 7.4) -4.52

Charge Density (pH 7.0) -0.0060

GRAVY Index0.04

Hydrophobic Moment 0.75

Boman Index0.14

Instability Index41.68

Aliphatic Index 98.81

Aromaticity 0.1051

Extinction Coeff. Reduced 69330.00

Extinction Coeff. Oxidized 69705.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0334894 VERIFIED: NO

Provenance & Taxonomy

OrganismMolossus molossus (Pallas` mastiff bat) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria