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MYP_138850
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Basic Information
1
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HCMV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
22 amino acids
C117H183N33O29S2
Standard
Sequence
LPRRLHLEPAFLPYSVKAHECC
Physicochemical Analysis
2580.04 Da
8.06
0.92
0.58
0.0417
-0.11
0.25
-0.00
81.98
93.18
0.0909
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
970.29
-5.66
35.0
34.0
78.0
181.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0033697 VERIFIED: YES
Provenance & Taxonomy
Human betaherpesvirus 5 [Virus]
Virus-derived peptide
10359;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Human cytomegalovirus UL54–UL44 protein interaction
11 μM
IC50 (protein-protein interaction inhibition)
PaperInhibition of human cytomegalovirus DNA polymerase by C-terminal peptides from the UL54 subunit. | Loregian A, Rigatti R, Murphy M, Schievano E, Palu G, Marsden HS. | J Virol. 2003 | PMID:12857903 PMID12857903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12857903/
RECORD: Rec_0060317 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 12857903 PMID12857903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12857903/
RECORD: Rec_0105661 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Human cytomegalovirus UL54–UL44 protein interaction
11 μM
IC50 (protein-protein interaction inhibition)
PaperPubMed PMID: 12857903 PMID12857903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12857903/
RECORD: Rec_0131285 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCMV
Human cytomegalovirus UL54–UL44 protein interaction
11 μM
IC50 (protein-protein interaction inhibition)
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperInhibition of human cytomegalovirus DNA polymerase by C-terminal peptides from the UL54 subunit. | Loregian A, Rigatti R, Murphy M, Schievano E, Palu G, Marsden HS. | J Virol. 2003 Aug;77(15):8336-44. | DOI:10.1128/jvi.77.15.8336-8344.2003 | PMID:12857903 PMID12857903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12857903/
RECORD: Rec_0246858 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 13.6%, E 0.0%, T 50.0%, C 36.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/