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MYP_138782
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Basic Information
L-Polyphemusin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C108H164N38O21S4
Standard
Sequence
RRWCFRVCYRGFCYRKCR
Physicochemical Analysis
2458.96 Da
10.33
6.72
6.45
0.3732
-0.83
0.71
-0.57
49.58
16.11
0.2778
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1011.69
-7.54
45.0
32.0
78.0
171.0
6.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0074827 VERIFIED: YES
Provenance & Taxonomy
Limulus Polyphemus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
MIC Escherichia coli
PMID27331141 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27331141/
RECORD: Rec_0119389 VERIFIED: YES
Provenance & Taxonomy
Limulus polyphemus [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
4-17, 8-13
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Yeasy: Candida albicans
4 μg/mL
MIC
PMID2514185;15134657 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2514185/
RECORD: Rec_0130180 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Tachyplesin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
3-16, 7-12
Bio-Activity Profile
Antimicrobial Antibacterial
PaperMiyata T, Tokunaga F, Yonega T, Yoshikawa K, Iwanaga S, Niwa M, Takao T, Shimonishi Y.. Antimicrobial peptides, isolated from horseshoe crab hemocytes, tachyplesin II, and polyphemusins I and II: chemical structures and biological activity. J. Biochem., 106, 663-668, 1989.
RECORD: Rec_0132415 VERIFIED: YES
Provenance & Taxonomy
Limulus polyphemus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0141493 VERIFIED: YES
Provenance & Taxonomy
Limulus Polyphemus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
2 μg/mL
PMID27331141 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27331141/
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