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MYP_138782
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Basic Information
L-Polyphemusin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C108H164N38O21S4
Standard
Sequence
RRWCFRVCYRGFCYRKCR
Physicochemical Analysis
2458.96 Da
10.33
6.72
6.45
0.3732
-0.83
0.71
-0.57
49.58
16.11
0.2778
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1011.69
-7.54
45.0
32.0
78.0
171.0
6.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007248 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human RBCs
1885 μg/mL
IC50
PMID28453851 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28453851/
RECORD: Rec_0016511 VERIFIED: YES
Provenance & Taxonomy
Limulus polyphemus [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
4-17, 8-13
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PMID2514185;15134657 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2514185/
RECORD: Rec_0017080 VERIFIED: YES
Provenance & Taxonomy
Limulus polyphemus [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
4-17, 8-13
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa Z61
1 μg/mL
MIC
PMID2514185;15134657 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2514185/
RECORD: Rec_0026960 VERIFIED: YES
Provenance & Taxonomy
Limulus polyphemus [Animal]
Tachyplesin polyphemusin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Gram-negative and Gram-positive bacteria
PMID2514185;15134657 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2514185/
RECORD: Rec_0030834 VERIFIED: YES
Provenance & Taxonomy
Limulus Polyphemus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae
PMID27331141 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27331141/
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