Peptide Database

Peptide NameSLAY-screened peptide P5157

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length6 amino acids

Chemical FormulaC30H39N9O8

DescriptionStandard

        SGAHWP
    

Molecular Weight653.69 Da

Isoelectric Point (pI)6.46

Net Charge (pH 7.0)-0.45

Net Charge (pH 7.4) -0.71

Charge Density (pH 7.0) -0.0755

GRAVY Index-0.85

Hydrophobic Moment 0.22

Boman Index0.24

Instability Index-24.77

Aliphatic Index 16.67

Aromaticity 0.1667

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 264.73

LogP -2.34

H-bond Donors 9.0

H-bond Acceptors 9.0

Rotatable Bonds 15.0

Heavy Atoms 47.0

Ring Count 4.0

Amide Bonds 5.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0008102 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/