Peptide Database

Peptide NameBrevinin-2PRa

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC173H291N47O48S3

DescriptionStandard

        GLMSLFKGVLKTAGKHIFKNVGGSLLDQAKCKITGEC
    

Molecular Weight3893.64 Da

Isoelectric Point (pI)9.51

Net Charge (pH 7.0)3.83

Net Charge (pH 7.4) 3.53

Charge Density (pH 7.0) 0.1034

GRAVY Index0.18

Hydrophobic Moment 0.61

Boman Index0.13

Instability Index24.76

Aliphatic Index 94.86

Aromaticity 0.0541

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1537.42

LogP -14.62

H-bond Donors 55.0

H-bond Acceptors 56.0

Rotatable Bonds 138.0

Heavy Atoms 271.0

Ring Count 3.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0423701 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pirica [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphlococcus aureus NCTC 8325

Activity25 μM

MethodMIC

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