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MYP_138459
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
33 amino acids
C148H255N41O41S3
Standard
Sequence
GIMSLFKGVLKTAGKHVAGSLVDQLKCKITGGC
Physicochemical Analysis
3361.05 Da
9.60
3.82
3.53
0.1159
0.45
0.60
0.20
-0.37
103.33
0.0303
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1314.61
-13.06
48.0
49.0
118.0
233.0
2.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0256765 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
33208
Structure & Mods
disulfide-constrained Rana-box peptide [Cyclic]
canonical L-amino-acid peptide [L]
Rana-box disulfide cyclization
27-33
Bio-Activity Profile
Antimicrobial
Gram-positive and Gram-negative bacteria; Candida albicans; human erythrocytes
MIC/erythrocyte hemolysis panel
PMID16979798 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16979798/
RECORD: Rec_0257755 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
Structure & Mods
disulfide-constrained Rana-box peptide [Cyclic]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Rana-box disulfide cyclization
27-33
Bio-Activity Profile
Hemolytic Cytolytic
Human erythrocytes
100.0 μM
LD50
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 143 (2006) 42-49. Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis PMID16413829
RECORD: Rec_0268021 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
Structure & Mods
disulfide-constrained Rana-box peptide [Cyclic]
canonical L-amino-acid peptide [L]
Rana-box disulfide cyclization
27-33
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus NCTC 8325 or MRSA
12.5-25 μM
MIC
PaperAntimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis PMID16413829
RECORD: Rec_0272248 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
Structure & Mods
disulfide-constrained Rana-box peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa ATCC 27853
6 μM
MIC
PMID16413829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16413829/
RECORD: Rec_0314514 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
Structure & Mods
disulfide-constrained Rana-box peptide [Cyclic]
canonical L-amino-acid peptide [L]
Rana-box disulfide cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus NCTC 8325
12.5 μM
MIC
PMID16413829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16413829/
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