‹ ›
MYP_138459
← PREVIOUS NEXT → BACK
Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
33 amino acids
C148H255N41O41S3
Standard
Sequence
GIMSLFKGVLKTAGKHVAGSLVDQLKCKITGGC
Physicochemical Analysis
3361.05 Da
9.60
3.82
3.53
0.1159
0.45
0.60
0.20
-0.37
103.33
0.0303
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1314.61
-13.06
48.0
49.0
118.0
233.0
2.0
33.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0222704 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
Enterobacter cloacae HNTCC 5300
6 μM
MIC
PaperAntimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis
RECORD: Rec_0225241 VERIFIED: YES
Provenance & Taxonomy
Rana kukunoris [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0233262 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
3.0 μM
MIC
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 143 (2006) 42-49. Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis
RECORD: Rec_0239922 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
Enterococcus faecalis ATCC 29212
25 μM
MIC
PaperAntimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis
RECORD: Rec_0241334 VERIFIED: YES
Provenance & Taxonomy
Rana tsushimensis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Klebsiella pneumoniae KK3 9904
6 μM
MIC
PMID16413829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16413829/
FIRST PREV 1 ... 3 4 5 6 7 ... 9 NEXT LAST
Showing 5 records on this page · Page 5 of 9