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MYP_138329
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Basic Information
Bombolitin IV
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
17 amino acids
C88H157N23O21
Standard
Sequence
INIKDILAKLVKVLGHV
Physicochemical Analysis
1873.33 Da
9.70
1.85
1.59
0.1086
1.00
0.66
0.30
29.91
194.71
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
716.05
-2.25
24.0
24.0
66.0
132.0
1.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0195651 VERIFIED: YES
Provenance & Taxonomy
American common [Animal]; Insecta [Animal]
33208; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID2578459 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2578459/
RECORD: Rec_0210945 VERIFIED: YES
Provenance & Taxonomy
Megabombus pennsylvanicus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxic Hemolytic
guinea pig erythrocytes
PMID2578459 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2578459/
RECORD: Rec_0220560 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
PaperArgiolas A., Pisano J. J.. Bombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus. J. Biol. Chem., 260, 1437-1444, 1985.
RECORD: Rec_0311289 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0373527 VERIFIED: YES
Provenance & Taxonomy
Megabombus pennsylvanicus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxic
PMID2578459 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2578459/
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