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MYP_138288
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Basic Information
Maculatin 3.1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
26 amino acids
C121H213N31O39
Standard
Sequence
GLLQTIKEKLESLESLAKGIVSGIQA
Physicochemical Analysis
2726.17 Da
6.23
-0.23
-0.45
-0.0090
0.26
0.57
0.16
17.38
138.85
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1147.88
-10.65
39.0
39.0
99.0
191.0
0.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0075427 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli TOP10
3.58 OD_ID (dimensionless)
Mex pooled growth-inhibition assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0091204 VERIFIED: NO
Provenance & Taxonomy
Litoria genimaculata [Animal]
Litoria genimaculate, Litoria eucnemis, Australia
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
PMID9620615;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9620615/
RECORD: Rec_0091769 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculata [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Streptococcus uberis
PaperPubMed PMID: 9620615 PMID9620615 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9620615/
RECORD: Rec_0106576 VERIFIED: YES
Provenance & Taxonomy
Litoria genimaculata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Pasteurella multocida
>100 μg/mL
MIC
PaperThe maculatin peptide from the skin glands of the tree frog Litoria genimaculata. A comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1 PMID9620615
RECORD: Rec_0127908 VERIFIED: NO
Provenance & Taxonomy
Litoria genimaculata,Litoria eucnemis [Animal]
Maculatin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperCancerPPD2 curated year-page record (1996–2000); partial row recovered from visible page. PMID9620615
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