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MYP_138254
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Basic Information
Nigrocin-2ISc
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
21 amino acids
C90H155N23O25S2
Standard
Sequence
GILSTVFKAGKGIVCGLSGLC
Physicochemical Analysis
2023.46 Da
8.90
1.74
1.50
0.0828
1.25
0.54
0.45
-8.68
125.24
0.0476
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
758.05
-7.46
29.0
29.0
68.0
140.0
1.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0245540 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Nigrocin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
15-21
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
50.0 μM
MIC
PaperE. Iwakoshi-Ukena et al. / BBRC 412 (2011) 673-677. Characterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning Evidence URLhttps://www.uniprot.org/uniprotkb/G3XHP1/entry
RECORD: Rec_0294091 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Nigrocin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
15-21
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
100 μM
MIC
PMID21867685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21867685/
RECORD: Rec_0340284 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0356823 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Escherichia coli
50 μM
MIC
RECORD: Rec_0384699 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Nigrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal
Bacillus subtilis
12.5 μM
MIC
PaperCharacterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning
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