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MYP_138254
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Basic Information
Nigrocin-2ISc
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
21 amino acids
C90H155N23O25S2
Standard
Sequence
GILSTVFKAGKGIVCGLSGLC
Physicochemical Analysis
2023.46 Da
8.90
1.74
1.50
0.0828
1.25
0.54
0.45
-8.68
125.24
0.0476
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
758.05
-7.46
29.0
29.0
68.0
140.0
1.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002488 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Staphylococcus aureus
3.1 μM
MIC
RECORD: Rec_0007030 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Nigrocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID21867685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21867685/
RECORD: Rec_0026876 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Nigrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus or MRSA
3.1-25 μM
MIC
PaperCharacterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning
RECORD: Rec_0059820 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Nigrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
50 μM
MIC
PaperCharacterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning
RECORD: Rec_0102632 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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