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MYP_138208
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Basic Information
Esculentin-2A (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
37 amino acids
C168H295N45O44S2
Standard
Sequence
GILSLVKGVAKLAGKGLAKEGGKFGLELIACKIAKQC
Physicochemical Analysis
3713.54 Da
9.70
4.74
4.49
0.1281
0.54
0.60
0.21
17.66
124.05
0.0270
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1430.98
-10.91
51.0
51.0
135.0
259.0
1.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0211195 VERIFIED: YES
Provenance & Taxonomy
Pelophylax esculentus [Animal]
Esculentin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
31-37
Bio-Activity Profile
Antimicrobial Antibacterial
PaperT. Chen et al. / Genomics 87 (2006) 638-644. Cloning from tissue surrogates: Antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs Evidence URLhttps://www.uniprot.org/uniprotkb/P40845/entry
RECORD: Rec_0215828 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Plant]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli D21
0.4 μM
MIC
PMID8163497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8163497/
RECORD: Rec_0235789 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0268329 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Plant]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
PMID8163497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8163497/
RECORD: Rec_0280924 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Esculentin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus megaterium BmII
0.2 μM
MIC
PMID8163497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8163497/
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