Peptide Database

Peptide NameSLAY-screened peptide P5777

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC121H164N24O29S

DescriptionStandard

        AFPIMPTYQRSFFTSYFYAI
    

Molecular Weight2450.80 Da

Isoelectric Point (pI)8.54

Net Charge (pH 7.0)0.79

Net Charge (pH 7.4) 0.60

Charge Density (pH 7.0) 0.0396

GRAVY Index0.38

Hydrophobic Moment 0.41

Boman Index0.33

Instability Index91.21

Aliphatic Index 49.00

Aromaticity 0.3500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 845.24

LogP -3.40

H-bond Donors 30.0

H-bond Acceptors 31.0

Rotatable Bonds 69.0

Heavy Atoms 175.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0122034 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/