Peptide Database

Peptide NameCholecystokinin-12

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Cell-cell communication

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC68H94N16O21S2

DescriptionStandard

        ISDRDYMGWMDF
    

Molecular Weight1535.70 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-2.24

Net Charge (pH 7.4) -2.44

Charge Density (pH 7.0) -0.1865

GRAVY Index-0.61

Hydrophobic Moment 0.30

Boman Index-0.00

Instability Index63.23

Aliphatic Index 32.50

Aromaticity 0.2500

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 613.47

LogP -3.49

H-bond Donors 22.0

H-bond Acceptors 21.0

Rotatable Bonds 48.0

Heavy Atoms 107.0

Ring Count 4.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0388760 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyGastrin/cholecystokinin

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other ModsTyr6 Sulfotyrosine

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide

RECORD: Rec_0395640 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyGastrin/cholecystokinin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other ModsTyr6 Sulfotyrosine

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide

RECORD: Rec_0415586 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyCholecystokinin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Other Mods6:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

TargetCCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Half-LifeMammalian: 20 hour; Yeast: 30 min; E. coli: >10 hour

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