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MYP_138060
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Basic Information
T-20S[138L]
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
36 amino acids
C205H304N50O63
Standard
Sequence
YTSLIHSLIEELQNQQEKNEQELLELDKWASLWNWF
Physicochemical Analysis
4476.90 Da
4.30
-5.14
-5.41
-0.1427
-0.75
0.55
-0.01
61.01
100.28
0.1389
17990.00
17990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1873.79
-12.90
62.0
59.0
151.0
318.0
9.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0274072 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 NL4-3 WT and resistant V38A/N43D/N43D-S138A variants; HeLa-derived MAGI cells
EC50 panel (MAGI assay)
PaperDesign of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20 PMID19073606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19073606/
RECORD: Rec_0294765 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0324105 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 V38A; HeLa-derived MAGI cells
0.013±0.006 μM
EC50 (MAGI assay)
PMID19073606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19073606/
RECORD: Rec_0379606 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 N43D; HeLa-derived MAGI cells
0.0029±0.0007 μM
EC50 (MAGI assay)
PMID19073606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19073606/
RECORD: Rec_0406230 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 NL4-3 V38A; HeLa-derived MAGI cells
0.013±0.006 μM
EC50 (MAGI assay)
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperDesign of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20. | Izumi K, Kodama E, Shimura K, Sakagami Y, Watanabe K, Ito S, Watabe T, Terakawa Y, Nishikawa H, Sarafianos SG, Kitaura K, Oishi S, Fujii N, Matsuoka M. | J Biol Chem. 2009 Feb 20;284(8):4914-20. | DOI:10.1074/jbc.M807169200 | PMID:19073606 PMID19073606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19073606/
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