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MYP_137981
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Basic Information
Islet amyloid polypeptide
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Standard
37 amino acids
C168H276N52O53S2
Standard
Sequence
KCNTATCATQRLTNFLVRSSHNLGAALPPTKVGSNTY
Physicochemical Analysis
3936.44 Da
9.85
3.82
3.54
0.1034
-0.29
0.64
-0.03
21.99
68.65
0.0541
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1715.61
-24.47
62.0
60.0
125.0
275.0
5.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0105943 VERIFIED: YES
Provenance & Taxonomy
Octodon degus [Animal]
Islet amyloid polypeptide
10160
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
2-7
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
Mammalian: 1.3 hour; Yeast: 3 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Islet amyloid polypeptide (Octodon degus): PMID 2293024 PMID2293024 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2293024/
RECORD: Rec_0275120 VERIFIED: YES
Provenance & Taxonomy
Octodon degus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0407180 VERIFIED: NO
Provenance & Taxonomy
Octodon degus [Animal]
Calcitonin
10160
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
2-7
Bio-Activity Profile
Hormone Calcium-regulatory peptide
Evidence URLhttps://www.uniprot.org/uniprotkb/IAPP_OCTDE/entry
RECORD: Rec_0425918 VERIFIED: NO
Provenance & Taxonomy
Octodon degus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone