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MYP_137853
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Basic Information
LL-37 KR-12 [Q5A,D9A]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C68H123N23O13
Standard
Sequence
KRIVARIKAFLR
Physicochemical Analysis
1470.85 Da
12.00
4.76
4.55
0.3965
0.17
0.71
-0.27
38.23
138.33
0.0833
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
621.16
-3.14
24.0
18.0
52.0
104.0
1.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0301226 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa ATCC 27853
1.25 μM
MIC
PMID29430821 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29430821/
RECORD: Rec_0331445 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 90028
2.5 μM
MIC
PMID29430821 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29430821/
RECORD: Rec_0357193 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID29430821 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29430821/
RECORD: Rec_0391341 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human histiocytic lymphoma U-937/GTB 10-20% Killing
100 μM
PMID29430821 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29430821/
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