Peptide Database

Peptide Nameoncostatin M

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Other / Curated residual function label ▸ Generic enzyme inhibition annotation

Standard StatusStandard

Sequence Length195 amino acids

Chemical FormulaC954H1546N296O284S9

DescriptionStandard

        AAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSR
    

Molecular Weight21994.88 Da

Isoelectric Point (pI)9.40

Net Charge (pH 7.0)7.21

Net Charge (pH 7.4) 6.66

Charge Density (pH 7.0) 0.0370

GRAVY Index-0.63

Hydrophobic Moment 0.81

Boman Index-0.16

Instability Index58.28

Aliphatic Index 80.10

Aromaticity 0.0564

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11710.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 9415.55

LogP -122.81

H-bond Donors 332.0

H-bond Acceptors 305.0

Rotatable Bonds 710.0

Heavy Atoms 1543.0

Ring Count 29.0

Amide Bonds 213.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0059278 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPredicted N-linked glycosylation of asparagine residues at positions 75 and 192; disulphide bond formation between cysteine residues at positions 6 and 127, and 49 and 167

Bio-Activity Profile

Function

Receptor agonist Enzyme inhibitory Signaling peptide

TargetLeukemia inhibitory factor receptor (Human); Oncostatin-M receptor (Human)