Peptide Database

Peptide NameBeta-defensin 133

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length62 amino acids

Chemical FormulaC335H513N85O79S8

DescriptionStandard

        MKIHIFLFVLFFFLVPIATRGVKCAVKDTYSCFIVRGKCRHECHDFEKPIGFCTKLNANCYM
    

Molecular Weight7251.70 Da

Isoelectric Point (pI)9.06

Net Charge (pH 7.0)4.70

Net Charge (pH 7.4) 4.23

Charge Density (pH 7.0) 0.0758

GRAVY Index0.45

Hydrophobic Moment 0.67

Boman Index0.16

Instability Index40.61

Aliphatic Index 84.84

Aromaticity 0.1613

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2605.46

LogP -14.42

H-bond Donors 97.0

H-bond Acceptors 95.0

Rotatable Bonds 236.0

Heavy Atoms 507.0

Ring Count 15.0

Amide Bonds 63.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0183893 VERIFIED: NO

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyDefensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KJ6/entry; https://bblserver.org.in/ampdb/