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MYP_137678
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Basic Information
Cecropin-A1/A2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Standard
40 amino acids
C183H311N61O53
Standard
Sequence
GWLKKIGKKIERVGQHTRDATIQGLGIAQQAANVAATARG
Physicochemical Analysis
4213.80 Da
11.07
4.85
4.59
0.1212
-0.39
0.94
-0.05
14.98
90.50
0.0250
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1883.21
-21.76
66.0
59.0
147.0
297.0
3.0
44.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0163033 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Natural peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium smegmatis ATCC 607
MIC
PMID3182836 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3182836/
RECORD: Rec_0171713 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0215370 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli D21
0.3 μM
MIC
PMID2390977 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2390977/
RECORD: Rec_0231343 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Cecropin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperEMBO J. 9:217-224(1990) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC551649/ Evidence URLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC551649/
RECORD: Rec_0281157 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus MI11
8.5 μM
MIC
PMID2390977 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2390977/
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