Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length482 amino acids

Chemical FormulaC2452H3915N633O680S19

DescriptionStandard

        MAWGPDNVRKWSSLALLAIVGTALTAATDPGFVARISQKGLDFVCQESMVELQKELLAISIPDFSGDFKIKHLGKGTYEFYSMAVEGFHIPDPQIKLLPSDGLQLSITSASIKISGRWKYRKNILKASGNFQLSIQGVSIIADLILGNDPSGRITITCSTCDSHINSVRIKVSGSMLGWLIQLFHRKIETSLKKTIYKKICKIVRNSVSAKLQPYVKTLPVVAKVDDITSIDYSLLAPPMTTDKFLEGQLRGEFFWRGHHGPFPAVPPVMNILPNNNYMVCMGISDYFFNTAEFAYQESETLKITLRDQLLAKDARYHLNTDFLKTFLPEVAKKFPSMGLQLLISAPLFAHLNIQPSGLSLSPNLETRAFVVLPNSSLIPLFLLGMKTNASLEVNAMKNRLIGEMKLGRLLLELKQSNFGSFKVELLEDVINYLMSTMVLPKINEKLRRGFPLPLPAGIQLINSILYSSQNFLLLEADLHRT
    

Molecular Weight53751.38 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)12.27

Net Charge (pH 7.4) 11.41

Charge Density (pH 7.0) 0.0255

GRAVY Index0.10

Hydrophobic Moment 0.86

Boman Index0.12

Instability Index34.31

Aliphatic Index 106.62

Aromaticity 0.0871

Extinction Coeff. Reduced 45380.00

Extinction Coeff. Oxidized 45630.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0196844 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyBPI/LBP

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram Negative Bacteria

RECORD: Rec_0269203 VERIFIED: NO

Provenance & Taxonomy

OrganismRanitomeya imitator [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria