Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length486 amino acids

Chemical FormulaC2406H3846N626O685S20

DescriptionStandard

        MFLCCWLVLGALIPATLSIDPGVKVRLTEKGIEYGRQLGMAAMQQKLNSIQVPDFSGKERVSPIGKVRYNFIRVLKVGIPKSSVDLVPGTGVTLSIGDAFISLNGRWKVKYLRIIGSFDLNVNGLNIATTISIKTDETGRPAVSSDSCSAAVGSAKVKFHGGGSWLYNLFTRFIDKALRNAMQKQICPRATSVVSDLNPQLKTLNVLAKVDKYAEIEYSMVSSPTVLKSSIDLSLKGEFYNIGKHQEPPFSPAAFNLPPQNNNMLYIGMSAFTVNSAAFVYNNAGVLSLSVTDDMIPKSSPIRLNTNTFGVIIPGIAKQFPGLMMKLLMKMEKIPTLTFETNNASVQATTTVTAFAIQTNSTLSPLFVLNLEASVSARMFVSEMKLAAAVTLNKMDLTLAKSNVGDFQVSALNSILQVVFKWVVIPTVNGEFILTLNFKEVFFTKISKKDFHLHFHSSSKVPGNIRQTTGGTSRIIVFNYICLDNY
    

Molecular Weight53143.36 Da

Isoelectric Point (pI)9.61

Net Charge (pH 7.0)17.90

Net Charge (pH 7.4) 17.26

Charge Density (pH 7.0) 0.0368

GRAVY Index0.17

Hydrophobic Moment 0.93

Boman Index0.14

Instability Index28.94

Aliphatic Index 99.05

Aromaticity 0.0885

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38640.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0315325 VERIFIED: NO

Provenance & Taxonomy

OrganismOreochromis aureus (Israeli tilapia) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria