Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length482 amino acids

Chemical FormulaC2402H3806N612O697S15

DescriptionStandard

        MLKVWYSFLLCLLALQLEANPGLKVRITQKGLDYGKTIGMELLKQAVLKETFPSWSGQETFSVVKVSYVISRLRIDDVDFPETSASFIPGTGISLSVAHASATISADWRMNTWLLKDQGGITVSISGLFIAVIFEVSRDSTGHLSVLLHNCQLSINSVKVKLNGGSSWIYSFLSGYIEKPIQTELHKNLCLNIKHKIQMMDGQLRKHQVLSQIDAFAQIDYSLVSSPTVFKSHINLDLKGTVYPVGNHTDPPFVPAPFALPDQGDSMLYLGVSSYFLKSASLAYYRAGAFNITVSEELATTFNLSTALCKDFVPEIALSNGTVCPVLLKLMATSPPVVSLNADRCILQITGSVEAFAVLPNSTTHYIFTGNLTASTRANLTITKQKLIISLLLKRLQVYLLHPTLGLSEQMSPMEDFLSYALRSAVIPVINDKLGKGFPLLNLAHTTLTGPVIKIEKGHLVISTDIHYEHEEGGDEDLDSHS
    

Molecular Weight52890.57 Da

Isoelectric Point (pI)6.57

Net Charge (pH 7.0)-2.22

Net Charge (pH 7.4) -3.39

Charge Density (pH 7.0) -0.0046

GRAVY Index0.18

Hydrophobic Moment 0.66

Boman Index0.17

Instability Index34.90

Aliphatic Index 107.99

Aromaticity 0.0830

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 50225.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0309506 VERIFIED: NO

Provenance & Taxonomy

OrganismLimosa lapponica baueri [Bacterium]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence