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MYP_137479
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
20 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
KKKKGFXGXKXGXFXGXGKX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0221097 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
X=A6c (1-aminocyclohexane carboxylic acid)
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: NCI-H69
2.2 μM
IC50
PaperAntibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(alpha) amino acids. Bioorg Med Chem. 2016 Sep 15;24(18):4056-4065. doi: 10.1016/j.bmc.2016.06.048. PMID: 27387357. PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0233820 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
X=A6c (1-aminocyclohexane carboxylic acid)
Bio-Activity Profile
Antimicrobial Anticancer
RL
3.7 μM
IC50
PaperAntibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(alpha) amino acids. Bioorg Med Chem. 2016 Sep 15;24(18):4056-4065. doi: 10.1016/j.bmc.2016.06.048. PMID: 27387357. PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0248558 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
X=A6c (1-aminocyclohexane carboxylic acid)
Bio-Activity Profile
Antimicrobial Anticancer
IGROV-1
7.5 μM
IC50
PaperAntibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(alpha) amino acids. Bioorg Med Chem. 2016 Sep 15;24(18):4056-4065. doi: 10.1016/j.bmc.2016.06.048. PMID: 27387357. PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0254359 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acetylation
Amidation
A6c = 1-aminocyclohexane carboxylic acid,
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis H37Rv
21.87 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0254875 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 7,9,11,13,15,17,20
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella aerogenes ATCC 13048
43.75 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
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